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Grey's Anatomy S05E22, What a Difference a Day MakesS05E22

Grey's Anatomy · Season 5

Grey's Anatomy season 5 episode 22: What a Difference a Day Makes

Aired 7 May 200943 minRated TV-14

8.7TMDB · 16 votesMark watched

Where to watch Grey's Anatomy Season 5 in Australia

Grey's Anatomy season 5 is streaming in Australia on Disney+ (subscription, listed for the whole show).

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Stream (subscription)

Availability checked 16 November 2026.

What happens in “What a Difference a Day Makes”

As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.

Episode summary: TMDB.

Before you watch

  • It is episode 22 of 24 of season 5, so watch episodes 1 to 21 first.
  • It runs about 43 minutes.
  • Directed by Rob Corn, written by Shonda Rhimes.
  • TMDB users rate it 8.7 out of 10 (16 votes).

Grey's Anatomy trailer

The official trailer for the series (no preview of this episode has been published).

Grey's Anatomy trailerPlay video: Grey's Anatomy trailer

Cast and crew of this episode

Director
Rob Corn
Writer
Shonda Rhimes
Guest stars
Jessica Capshaw as Arizona RobbinsMac Brandt as ParamedicMark Saul as SteveCandice Afia as Intern LauraJeffrey Dean Morgan as Denny DuquettePayton Silver as Dr. KnoxMolly Kidder as Intern MeganJoe Williamson as Intern Pierce

Credits: TMDB.

More from Grey's Anatomy Season 5

Previous · S05E21No Good at Saying Sorry (One More Chance)30 April 2009Next · S05E23Here's to Future Days14 May 2009
  1. E01
  2. E02
  3. E03
  4. E04
  5. E05
  6. E06
  7. E07
  8. E08
  9. E09
  10. E10
  11. E11
  12. E12
  13. E13
  14. E14
  15. E15
  16. E16
  17. E17
  18. E18
  19. E19
  20. E20
  21. E21
  22. E22
  23. E23
  24. E24

Every episode of Season 5Grey's Anatomy episode guide

Episode names, air dates, runtimes, stills and ratings: TMDB. Air dates are the first broadcast anywhere; where it streams is our daily Australian check.