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Grey's Anatomy S04E01, A Change Is Gonna ComeS04E01

Grey's Anatomy · Season 4

Grey's Anatomy season 4 episode 1: A Change Is Gonna Come

Aired 27 September 200743 minRated TV-14

8.3TMDB · 15 votesMark watched

Where to watch Grey's Anatomy Season 4 in Australia

Grey's Anatomy season 4 is streaming in Australia on Disney+ (subscription, listed for the whole show).

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Stream (subscription)

Availability checked 16 November 2026.

What happens in “A Change Is Gonna Come”

Entering their first year as residents, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new interns are George, forced to repeat his internship after failing his exams, and Lexie Grey, Meredith's half-sister. Another two new interns will be introduced in this season premiere. And they'll have their hands full when a three-car accident sends multiple casualties pouring into Seattle Grace. Some of the doctors need to deal with new stressed out interns. A young boy brings his bleeding deer to the hospital in the hope a doctor will save her.

Episode summary: TMDB.

Before you watch

  • It is the season premiere of season 4.
  • It runs about 43 minutes.
  • Directed by Michael Grossman and Rob Corn, written by Shonda Rhimes.
  • TMDB users rate it 8.3 out of 10 (15 votes).

Grey's Anatomy trailer

The official trailer for the series (no preview of this episode has been published).

Grey's Anatomy trailerPlay video: Grey's Anatomy trailer

Cast and crew of this episode

Directors
Michael GrossmanRob Corn
Writer
Shonda Rhimes
Guest stars
Mac Brandt as ParamedicGloria Garayua as Intern GraciellaCandice Afia as Intern LauraMark Pellegrino as ChrisRichard Keith as Intern MitchMolly Kidder as Intern MeganJoe Williamson as Intern PierceWinston Story as Intern Leo

Credits: TMDB.

More from Grey's Anatomy Season 4

Next · S04E02Love/Addiction4 October 2007
  1. E01
  2. E02
  3. E03
  4. E04
  5. E05
  6. E06
  7. E07
  8. E08
  9. E09
  10. E10
  11. E11
  12. E12
  13. E13
  14. E14
  15. E15
  16. E16

Every episode of Season 4Grey's Anatomy episode guide

Episode names, air dates, runtimes, stills and ratings: TMDB. Air dates are the first broadcast anywhere; where it streams is our daily Australian check.